Spotty brood usually means the queen is old or there is brood disease. Sunken brood capping with holes suggest most likely American Foulbrood, which can be a serious disease if left to develop. In most states, the bacteria causing this disease (Paenibacillus larvae) has become resistant to oxytetracycline (Terramycin). New medications (lincomycin and tylosin) are being applied for bee use. Photo by Zachary Huang.